Actemra/RoActemra is approved in 116 nations for rheumatoid arthritis (RA). The drug is also approved for systemic juvenile idiopathic arthritis (sJIA), pediatric juvenile idiopathic arthritis (pJIA), CAR-T cell-induced cytokine release syndrome (CRS), and giant cell arteritis (GCA). This medicinal product is available in both intravenous (IV) and subcutaneous (SC) formulations.
Actemra/RoActemra is a first-in-class aIL-6R therapy, believed to play a significant role in activating the inflammatory pathway that causes signs and symptoms of rheumatoid arthritis and other inflammatory autoimmune complications. It binds to IL-6 receptors, inhibiting the pro-inflammatory consequences of IL-6 cytokines.
The medicine is approved for defined patients hospitalized with serious or critical COVID-19 in different territories including Japan, European Union (EU), Ecuador, Peru, Honduras, Myanmar, Ukraine, and the UK. It is provisionally approved in Australia and is authorized for emergency use in the US and Ghana. It has also been recommended by the specialized agency of the UNs responsible for international public health named WHO.
Several studies have assessed the efficacy and safety of Actemra/RoActemra. The UN agency has also reported that IL-6 receptor inhibitors, such as Actemra/RoActemra, are expected to still be promising against the SARS-CoV-2 variant of concern, Omicron (B.1.1.529).
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